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Research |
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Research Programs |
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Analytical Chemistry |
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Atomic spectroscopy; sample introduction methods for atomic sources; automation in chemical analysis; analytical techniques for environmental pollutants and food additives; capillary and microchip capillary electrophoresis; biological mass spectrometry in proteomics applications. |
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Chemical Biology |
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Structure determination of biomolecules; interaction, dynamics and functional studies of biomolecules and drugs (and metallodrugs); development of new experimental and computational methods for high throughput structure determination of biomolecules by NMR spectroscopy.
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DNA condensation by nanopolymer
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Schematic illustration of the nanopolymer structure |
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The globular morphology of the nanopolymer/DNA polyplexes as observed under the transmission electronic microscope (TEM) |
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In vitro transfection efficiency of the nanopolymer carrying the EGFP plasmid in cells; |
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In vivo transfection efficiency of the nanopolymer carrying the firefly luciferase plasmid (pLuc) in mice. Bioluminescent imaging of luciferase expression was determined and quantified in living mice using a cooled CCD camera at 24 hours after intravenous injection of the nanopolymer/pLuc polyplexes |
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Inorganic Chemistry |
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Inorganic and organometallic photochemistry (including studies in microheterogeneous media); asymmetric synthesis and organic oxidation using metal complexes; structure and properties of high nuclearity metal clusters; biomimetic models for nitrogen transfer reactions; chemistry of lanthanides; metal-alkylidyne and -alkylidene complexes; metal-protein interactions; supramolecular chemistry; molecular recognition and chemosensing; recognition and cleavage of DNA by metal complexes; molecular metal-based materials with novel properties. |
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| Intermolecular hydrogen-bonded 1D chain of novel pentameric water cluster running along the crystallographic b-axis in complex 2 |
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Materials Science |
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Light emitting materials; nanoparticles; catalysts and materials for green oxidation; materials for organic solar cells. |
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Organic Chemistry |
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Organic Chemistry Synthetic organic chemistry: new synthetic methods, asymmetric catalysis, total and enantioselective synthesis of natural products; chemical biology of natural products; chemical and biological oxidation reactions; design, synthesis and applications of foldamers and peptidomimetics; drug design and synthesis. |
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Merged image, co-stained with three probes |
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DAPI (for nuclei, blue color) |
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HKGreen-4 (for ONOO-, green color) |
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MitroTracker ® Red CMXRos [M7512] (for mitochondrion, red color) |
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Polymer Chemistry and Synthesis |
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Synthesis and characterization of polymers with potential applications in photonics, electronics, and organic transformations. |
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Physical Chemistry |
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Molecular simulation: Monte Carlo and molecular dynamics calculations; electrochemistry: scanning probe microscopy, fuel cells and sensors, advanced lithium battery, electroplating techniques; molecular reaction kinetics and dynamics; solution phase chemical dynamics; theoretical investigation of electrical and optical properties of polymeric materials; theoretical and computational biophysics including protein folding and charge transfer in biomolecules; reaction mechanisms and chemical intermediates; physical organic chemistry; energetics, structures and mechanisms of gas-phase ions fragmentation. |
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| DNA base adenine |
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DNA oligomer A20 |
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Spectroscopy/Spectrometry |
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High resolution laser and IR spectroscopy; NMR: new pulse sequences employing magnetic field gradients; ultrafast time-resolved spectroscopy; time-resolved resonance Raman spectroscopy; mass spectrometry.
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X-Ray Crystallography |
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Structural chemistry, solid-state chemistry.
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